The crash happened between Exit PA 23 West-Walnut Street and Exit PA 23 East-New Holland Pike in East Lampeter Township around 3:26 p.m., according to emergency dispatchers and PennDOT.
All lanes were closed and traffic was diverted to the Walnut Street exit while crews remained on the scene.
It is unclear if anyone was hurt in the crash.
The roadway reopened shortly before 7 p.m.
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